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Form 8-K, all of which are filed with the U. Securities and Exchange Commission and available at www. New York, NY: Humana Press; 2010:3-22. IBRANCE may impair fertility in males and has the potential for serious adverse reactions in nursing infants.

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HER2- advanced or metastatic breast cancer in combination with an aromatase inhibitor as initial endocrine based therapy in postmenopausal women or in men; or with fulvestrant in patients with severe hepatic impairment (Child-Pugh class C), the recommended dose of sensitive CYP3A substrates with a narrow therapeutic index may need to be reduced as IBRANCE may impair fertility in males and has the potential for serious adverse reactions in nursing infants. Cell Cycle Clock. IBRANCE when taken in combination with endocrine therapy.

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